Remedies Containing Agarwood in Selected Traditional Malay Medical Manuscripts (Ubatan Tradisional Mengandungi Gaharu di dalam Manuskrip Perubatan Melayu Tradisional)

UMMU ATHIYAH MOHAMMAD TORMIZI, NURHUSNA SAMSUDIN, YUMI ZUHANIS HAS-YUN HASHIM, ANIS NAJIHA AHMAD, ASMAK MUTIAH MOHD NASIR, NUR UMISHA ZAINUDIN

Abstract


ABSTRACT: Agarwood (Aquilaria spp.) is an Asian native plant with various pharmaceutical potentials proven by recent scientific studies. It has been used for decades in ancient India, China, and the Malay Archipelago traditions. Ayurvedic and traditional Chinese medicine have been widely accepted and integrated into the current medical system. Regrettably, the traditional medicine of the Malay people has not reached this desired level despite the availability of knowledge as recorded in the Traditional Malay Medical (TMM) manuscripts. Agarwood is one of the materials observed in the traditional remedy formulations in TMM. Therefore, this work aims to explore the remedies in the TMM manuscripts with a focus on agarwood. Seven TMM manuscripts: MSS 2999, MSS 2515, MS 1998.400, Khazanah Perubatan Melayu Tumbuhan Ubatan, Kitab Tib Ilmu Perubatan Melayu, Khazinat al-Insan and Kitab al-Rahmah Fi al-Tibb wa alHikmah in the collection of the Malaysia National Library were reviewed systematically. The study finds around 100 agarwood-related formulations to treat around 20 diseases, including inner and physical illnesses, a specific approach to explicate the remedy that includes a discussion on selected Quranic verse and taboos, different sources of materials; plants, animals, and minerals, definitions on selected processing and dosing terms, three main methods to extract the materials; direct extraction, through heating or cooling, and maceration, and two ways to take the remedy; orally or externally. Findings from this study can be used as a reference for the practical application of the Malay traditional medication into current scientific development, verifying the relevancy of the discovery of new evident-based alternative medicine while safeguarding TMM as a national heritage.

Keywords: Agarwood; Aquilaria spp.; ethnomedicine; Traditional Malay Medical manuscripts

 

ABSTRAK: Gaharu (Aquilaria spp.) ialah tumbuhan Asia dengan pelbagai potensi farmaseutikal yang dibuktikan oleh kajian saintifik terkini dan telah digunakan dalam tradisi lama India, China, dan Kepulauan Melayu. Perubatan Ayurveda dan perubatan tradisional Cina telah diterima secara meluas dan disepadukan ke dalam sistem perubatan arus perdana. Malangnya, perubatan tradisional Melayu masih belum mencapai tahap yang diidamkan walaupun terdapat ilmu seperti yang tercatat dalam manuskrip Perubatan Melayu Tradisional (PMT). Gaharu adalah salah satu bahan yang seringkali dimanfaatkan dalam penghasilan ubat tradisional Melayu. Oleh itu, kajian ini bertujuan untuk meneroka formulasi dalam manuskrip PMT dengan memberi tumpuan kepada kayu gaharu. Tujuh manuskrip PMT iaitu MSS 2999, MSS 2515, MS 1998.400, Khazanah Perubatan Melayu Tumbuhan Ubatan, Kitab Tib Ilmu Perubatan Melayu, Khazinat al-Insan and Kitab al-Rahmah Fi al-Tibb wa al-Hikmah di bawah koleksi Perpustakaan Negara Malaysia telah disemak secara sistematik. Kajian menemui lebih kurang 100 formulasi untuk merawat lebih kurang 20 penyakit termasuk penyakit dalaman dan fizikal, satu pendekatan khusus dalam menerangkan formulasi yang merangkumi perbincangan tentang ayat al-Quran dan pantang larang terpilih, sumber bahan yang berbeza; tumbuhan, haiwan, dan mineral, definisi mengenai terma pemprosesan dan dos terpilih, tiga kaedah utama untuk mengekstrak bahan; pengekstrakan terus, melalui pemanasan atau penyejukan, dan melalui pemerahan, serta dua cara untuk mengambil ubat itu; sama ada ditelan atau penggunaan secara luaran. Penemuan daripada kajian ini boleh digunakan sebagai rujukan untuk mengaplikasikan ubatan tradisional Melayu ke dalam pembangunan perubatan semasa, mengesahkan kerelevanan terhadap penemuan perubatan alternatif berasaskan bukti baharu sekaligus memelihara PMT sebagai warisan negara.

Kata kunci: Gaharu; Aquilaria spp.; etnoperubatan; manuskrip perubatan Melayu tradisional


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References


Ahad, A., Ganai, A.A., Sareer, O., Najm, M.Z., Kausar, M.A., Mohd, M. & Siddiqui, W.A. 2012. Therapeutic potential of Oroxylum indicum: A review. Journal of Pharmaceutical Research And Opinion 2(10):163 72.

Biswas, S. K., Dana, S., Pathak, P.S. & Gupta, M. 2022. In vitro anti diabetic and anti-oxidant activities of Oroxylum indicum (Kurtz): A potent wild medicinal plant NorthEastern region in India. Journal of Pharmacognocy and Phytochemistry 11(5): 38-44.

Chamikara, M.D.M, Dissanayake, D.R.R.P., Ishan, M. & Sooriyapathirana, S.D.S.S. 2016. Dietary, anticancer and medicinal properties of the phytochemicals in chili pepper (Capsicum Spp.). Ceylon Journal of Science 45(3): 5.

El-Baroty, G.S., Abd El-Baky, H.H., Farag, R.S. & Saleh, M.A. 2010. Characterization of antioxidant and antimicrobial compounds of cinnamon and ginger essential oils. African Journal of Biochemistry Research 4(6): 167-74.

Elias, M.F., Ibrahim, H. & Wan Mahamod, W.R. 2017. A review on the Malaysian Aquilaria species in karas plantation and agarwood production. International Journal of Academic Research in Business and Social Sciences 7(4): 1021-1029.

Francois-Newton, V., Brown, A., Andres, P., Mandary, M.B., Weyers, C., Latouche-Veerapen, M. & Hettiarachchi, D. 2021. Antioxidant and anti-aging potential of Indian sandalwood oil against environmental stressors in vitro and ex vivo. Cosmetics 8:53.

Hashim, Y.Z.H.Y., Kerr, P.G., Abbas, P. & Mohd Salleh, H. 2016. Aquilaria Spp. (agarwood) as source of health beneficial compounds: a review of traditional use, phytochemistry and pharmacology. Journal of Ethnopharmacology 189(2016): 331-360

Hassan, M. & Ramakrishnan, R. 2013. Anticancer properties of Zingiber officinale-ginger: a review. International Journal of Medicine and Pharmaceutical Sciences (IJMPS) 3:11-20.

Mas’oad, M.D., Mohammad, M. & Mohd Shafri, M.A. 2020. Rawatan kanser dalam beberapa manuksrip Melayu terpilih. In Mohd Shafri MA (ed). Manuskrip Perubatan Melayu: Warithan Kebitaraan Melayu, 29-59. Kuala Lumpur: Akademi Jawi Malaysia.

Mat Piah, H. 2015. Ilmu perubatan melayu tradisional dari naskhah-naskhah lama. Jurnal Antarabangsa Alam Dan Tamadun Melayu 3(3):3-17.

Miraj, S. & Kiani, S. 2016. Pharmacological activities of Carum Carvi L. Der Pharmacia Lettre 8:135-138.

Misra, B. & Dey, S. 2013. Evaluation of in vivo antihyperglycemic and antioxidant potentials of α-santalol and sandalwood oil. Phytomedicine 20(5): 409-416. Ngadeni, N. 2017. Falsafah Dan Prinsip Asas Perubatan Melayu. Pulau Pinang: Baytul Hikma

Nouroz, F., Mehboob, M., Noreen, S., Zaidi, F. & Mobin, T. 2015. A review on anticancer activities of garlic (Allium Sativum L.). Middle-East Journal of Scientific Research 23(6): 1145–1151. Palatty, P.L., Haniadka, R.,

Valder, B., Arora, R. & Baliga, M.S. 2013. Ginger in the prevention of nausea and vomiting: a review. Critical Reviews in Food Science and Nutrition 53(7):659-669.

Paul, S., Sheikh, H., Sikder, S., Paul, S.K., Hasan, A.R., Rahaman, M. & Kundu, S.P. 2013. Hypoglycemic, anti-inflammatory and analgesic activity of Peperomea

pellucida (L.) HBK (piperaceae). International Journal of Pharmaceutical Science and Research 4(1):458-463.

Rasool, S. & Mohamed, R. 2016. Understanding Agarwood formation and its challenges. In Mohamed R (ed). Agarwood. New York: Springer.

Salari Rafsanjani, M., Tabatabaei Naeini, A., Meimandi-Parizi, A., Nowzari, F., Mujtaba Wani, M. & Iraji, A. 2022. Wound healing effect of Carum carvi L. on the incised skin wound in male rats: Histopathology, total protein and biomechanical evaluations. Veterinary Medicine and Science 1-12.

Santha, S. & Dwivedi, C. 2015. Anticancer effects of sandalwood

(Santalum album). Anticancer Research 35(6):145-150.

Sharma, S., Raj, K., Riyaz, M. & Singh, D.D. 2022. Antimicrobial Studies on Garlic Lectin. Probiotics &

Antimicrobial Protein.

Yang, J.J. & Rahmawati, F. 2022. Antimicrobial effects of various red ginger (Zingiber officinale) extract

concentrations on Escherichia coli bacteria. European Journal of Biotechnology and Bioscience 10(2): 63-67.

Yang, Y., Zhang, Z., Li, S., Ye, X., Li, X. & He, K., 2014. Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis. Fitoterapia 92:133-147.

Yuan, H., Ma, Q., Cui, H. Liu, G., Zhao, X., Li, W. & Piao, G. 2017. How can synergism of traditional medicines benefit from network pharmacology?. Molecules 22:1135.

Zamri, N. & Abd Hamid, H. 2019. Comparative study of onion (Allium cepa) and leek (Allium ampeloprasum): identification of organosulphur compounds by UPLC-QTOF/ MS and anticancer effect on MCF-7 cells. Plant Foods for Human Nutrition 74(4):525-530


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